- Title
- Human Vestibulo-Ocular Reflex Adaptation Reduces when Training Demand Variability Increases
- Creator
- Rinaudo, CARLO N.; Schubert, MICHAEL C.; Figtree, WILLIAM V. C.; Cremer, PHILLIP D.; Migliaccio, AMERICO A.
- Relation
- JARO - Journal of the Association for Research in Otolaryngology Vol. 22, Issue 2, p. 193-206
- Publisher Link
- http://dx.doi.org/10.1007/s10162-020-00775-y
- Publisher
- Springer
- Resource Type
- journal article
- Date
- 2021
- Description
- One component of vestibular rehabilitation in patients with vestibulo-ocular reflex (VOR) hypofunction is gaze-stabilizing exercises that seek to increase (adapt) the VOR response. These prescribed home-based exercises are performed by the patient and thus their use/training is inherently variable. We sought to determine whether this variability affected VOR adaptation in ten healthy controls (× 2 training only) and ten patients with unilateral vestibular hypofunction (× 1 and × 2 training). During × 1 training, patients actively (self-generated, predictable) move their head sinusoidally while viewing a stationary fixation target; for × 2 training, they moved their outstretched hand anti-phase with their head rotation while attempting to view a handheld target. We defined the latter as manual × 2 training because the subject manually controls the target. In this study, head rotation frequency during training incrementally increased 0.5–2 Hz over 20 min. Active and passive (imposed, unpredictable) sinusoidal (1.3-Hz rotations) and head impulse VOR gains were measured before and after training. We show that for controls, manual × 2 training resulted in significant sinusoidal and impulse VOR adaptation of ~ 6 % and ~ 3 %, respectively, though this was ~two-thirds lower than increases after computer-controlled × 2 training (non-variable) reported in a prior study. In contrast, for patients, there was an increase in impulse but not sinusoidal VOR response after a single session of manual × 2 training. Patients had more than double the variability in VOR demand during manual × 2 training compared to controls, which could explain why adaptation was not significant in patients. Our data suggest that the clinical × 1 gaze-stabilizing exercise is a weak stimulus for VOR adaptation.
- Subject
- vestibulo-ocular reflex (VOR); VOR adaptation; variability of training demand; × 1 and × 2 training; incremental frequency adaptation; vestibular rehabilitation gaze-stabilizing exercises
- Identifier
- http://hdl.handle.net/1959.13/1452270
- Identifier
- uon:44394
- Identifier
- ISSN:1525-3961
- Language
- eng
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